7 Fabrics to Avoid with MCS and Better Alternatives to Wear

Multiple Chemical Sensitivity (MCS) can make everyday clothing a source of discomfort and irritation. This guide outlines seven common fabrics to avoid and suggests safer alternatives made without harsh chemicals or synthetic treatments.

We often think of clothing as a basic necessity, something chosen for style, comfort, or function. However, for people with chemical sensitivities, what touches the skin can be just as important as what goes into the body. Sometimes, everyday fabrics can contribute to discomfort, irritation, or severe health reactions.

Multiple Chemical Sensitivity (MCS), sometimes called Idiopathic Environmental Illness (IEI), is a chronic condition in which people experience adverse reactions to low levels of common chemicals in everyday environments. These chemicals may be present in household cleaners, building materials, personal care products, and clothing. While MCS is still under ongoing research and debate within the medical community, it’s widely recognized that chemical sensitivity can seriously affect the quality of life; thus, awareness is necessary.

The symptoms of MCS vary from person to person, but common complaints include headaches, fatigue, difficulty concentrating, dizziness, nausea, respiratory issues, skin rashes, and muscle or joint pain. In some cases, even trace amounts of chemicals—undetectable to most people—can trigger intense reactions. This makes everyday activities, including getting dressed, a potential source of physical stress.

Because of this, individuals with MCS are often advised to limit exposure to chemical irritants, particularly those found in fabrics. Many textiles today are treated with dyes, synthetic resins, flame retardants, and other chemical finishes that can exacerbate MCS symptoms. Exploring safer alternatives, such as untreated, natural fabrics free from synthetics and chemical treatments, can provide meaningful relief and greater control over one’s environment.

Below are seven types of fabrics or fabric treatments that individuals with MCS should avoid, along with safer alternatives that can reduce the risk of reactions.

1. Synthetic Fabrics (Polyester, Nylon, Acrylic, Spandex)

Fabrics made from petroleum-based materials often contain residual chemicals from the manufacturing process. They trap heat and moisture, exacerbating skin irritation and releasing volatile organic compounds (VOCs) that may aggravate MCS symptoms.

Better Alternative: Choose natural, untreated fabrics like 100% organic cotton. Look for clothing free from latex, spandex, and synthetic finishes, available from brands specializing in hypoallergenic apparel, such as Cottonique.

2. Wrinkle-Resistant and Stain-Resistant Fabrics

These convenience-focused fabrics are typically treated with formaldehyde-based resins and perfluorinated compounds (PFCs), which can off-gas harmful fumes over time and trigger sensitivities.

Better Alternative: Opt for untreated natural fibers like pure cotton or linen. While they may wrinkle more easily, they offer breathability and softness without the risk of chemical exposure.

3. Dyed and Colored Fabrics with Synthetic Dyes

Brightly colored garments are often dyed with synthetic or azo-based dyes, which can contain heavy metals or release aromatic amines, chemicals linked to skin irritation and other health concerns.

Better Alternative: Stick to undyed or naturally colored fabrics. If color is important, choose items dyed with low-impact or plant-based dyes, and always check for transparency in the dyeing process.

4. Chemically Treated Fabrics with Fragrances and Softeners

Many mass-market garments are finished with softeners or scented treatments to create a pleasant feel or smell. Unfortunately, these often include phthalates, artificial fragrances, and chemical residues that can trigger reactions in individuals with chemical sensitivities.

Better Alternative: Choose clothing that states it’s free from added fragrances and fabric treatments. Brands like Cottonique avoid using softeners, resins, and fragrances during production. Washing new clothes in a fragrance-free detergent can also help remove residual irritants.

5. Blended Fabrics (e.g., Cotton-Polyester, Cotton-Spandex)

Blends may appear breathable or stretchy, but even a small percentage of synthetic material can introduce unwanted chemical additives. They also typically undergo chemical finishing treatments to stabilize the blend.

Better Alternative: Stick with 100% natural, single-fiber fabrics. Many specialty brands offer garments made entirely from untreated cotton, with no blends or elastic fibers that could irritate.

6. Flame-Retardant Fabrics

Sleepwear and children’s clothing are often treated with flame-retardant chemicals to comply with safety standards. These treatments can contain brominated or phosphorus-based compounds that may disrupt hormones or cause skin reactions.

Better Alternative: Look for untreated natural fabrics, such as organic cotton, which have a lower flammability than many synthetics and don’t require chemical flame-retardant coatings. Always check labels to ensure no additional flame-retardant treatments have been applied.

7. Waterproof or Water-Resistant Fabrics

Water-repellent materials are frequently treated with perfluorinated compounds or other barrier chemicals that can off-gas over time and trigger MCS symptoms.

Better Alternative: Layer breathable, untreated fabrics instead of relying on chemical barriers. Organic cotton is excellent for layering and helps regulate temperature without synthetic coatings.

Avoiding chemically treated fabrics can make a difference for people living with MCS. By choosing pure, untreated clothing made from organic cotton or other natural fibers, you can reduce exposure to potential irritants and feel more comfortable in your skin.